The role of PD-1/PD-L1 axis in idiopathic pulmonary fibrosis: Friend or foe?

The role of PD-1/PD-L1 axis in idiopathic pulmonary fibrosis: Friend or foe?

Blog Article

Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with a bleak prognosis.Mounting evidence suggests that IPF shares bio-molecular similarities with lung cancer.Given the deep understanding of the programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway in cancer immunity and the successful application of immune checkpoint inhibitors (ICIs) in lung cancer, recent studies have noticed the role of the PD-1/PD-L1 axis in IPF.However, the conclusions are ambiguous, and the latent mechanisms remain unclear.

In this review, we will bostik roll-cote summarize the role of the PD-1/PD-L1 axis glitter foam vellen action in IPF based on current murine models and clinical studies.We found that the PD-1/PD-L1 pathway plays a more predominant profibrotic role than its immunomodulatory role in IPF by interacting with multiple cell types and pathways.Most preclinical studies also indicated that blockade of the PD-1/PD-L1 pathway could attenuate the severity of pulmonary fibrosis in mice models.This review will bring significant insights into understanding the role of the PD-1/PD-L1 pathway in IPF and identifying new therapeutic targets.